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Syncytiotrophoblast

Localization Information

text version of image
image associated links:
basolateral genes: MRP5, OCT3, OAT4, OATP2B1
apical genes: MDR1, MRP1, MRP2, MRP3, BCRP, OCTN2

Notes:

The study of the maternal-fetal barrier is highly dynamic. As new information becomes available we will update this page.
The expression of transporters at this barrier has been shown to change throughout gestation (see Mikheev et al. Reprod Sci. 2008 Nov;15(9):866-77). The figure above represents the localization of transporters in a full-term placenta.
The arrows indicate the transporter's primary direction of transport. However, for some SLC transporters, transport in the opposite direction is also possible. For example, glutarate efflux is trans-stimulated by extracellular estrone-3-sulfate or para-aminohippurate in OAT4-expressing S2 cells (Ekaratanawong et al., J Pharmacol Sci. 2004 Mar;94(3):297-304).
The orange transporters OATP4A1, ATP7B, and ENT1 are shown, but not currently contained in our database.

Asterisk and bold rows indicates important transporters in the organ as identified in the organ diagram

Transporter	Synonyms	Relative Expression (Transporter mRNA/PPIA mRNA)
ABCB1*	MDR1, P-gp	`0.0255`
ABCB4	MDR3	`0.000122`
ABCB11	BSEP	BLQ
ABCC1*	MRP1	`0.0224`
ABCC2*	MRP2, cMOAT	`0.00311`
ABCC3*	MRP3	`0.0183`
ABCC4	MRP4	`0.00942`
ABCC5*	MRP5	`0.00803`
ABCC6	MRP6	`0.0000869`
ABCG2*	BCRP, MXR	`0.0954`
SLC10A1	NTCP	`0.00246`
SLC10A2	ASBT, SBAT2	BLQ
SLC15A1	PEPT1	`0.00635`
SLC15A2	PEPT2	`0.00131`
SLC22A1	OCT1	`0.0000830`
SLC22A2	OCT2	`0.0000884`
SLC22A3*	OCT3	`0.146`
SLC22A4	OCTN1	`0.00582`
SLC22A5*	OCTN2	`0.0338`
SLC22A6	OAT1	BLQ
SLC22A7	OAT2	`0.0000503`
SLC22A8	OAT3	BLQ
SLC22A11*	OAT4	`0.106`
SLC22A12	URAT1	BLQ
SLCO1A2	OATP1A2, OATP-A	`0.000130`
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	BLQ
SLCO2B1*	OATP2B1, OATP-B	`0.0557`

Samples obtained from females (n=8), 19 to 39-yr, Caucasian
BLQ = below limit of quantitation