Important Transporter Localization in the Syncytiotrophoblast
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| |
| MDR1 --->
| |
<--- MRP5 MRP1 --->
| |
| MRP2 --->
| |
OCT3 ---> MRP3 --->
Fetal | | Maternal
Blood | BCRP ---> Blood
| |
OAT4 ---> <--- OCTN2
| |
| <--- OATP4A1
| |
OATP2B1 ---> ATP7B --->
| |
| <--- ENT1 --->
| |
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Basolateral Apical
arrows denote primary direction of transport
OATP4A1, ATP7B and ENT1 are shown, but not currently contained in our database
The image shows a simplified cell outline with marked basolateral side facing fetal blood and the apical side facing maternal blood. MRP5 is an efflux transporter placed on the basolateral side. OCT3, OAT4, and OATP2B1 are basolateral influx transporters. MDR1, MRP1, MRP2, MRP3, BCRP, and ATP7B are efflux transporters on the apical side. OCTN2, OATP4A1, and ENT1 are apical influx transporters, while ENT1 is a bi-directional transporter on the apical membrane. OATP4A1, ATP7N, and ENT1 are shown on the image but not in the database.