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mouse Abcb1b

Synonyms: mdr, Mdr1, Pgy1, Abcb1, Mdr1b, Pgy-1

Entrez Gene Link

Expression Data
Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

Expression Data

Expression data for other tissues could be found in http://pharmacogenetics.ucsf.edu/gtex/index.html

No expression data.

In Vitro Substrates

No substrate information.

In Vitro Inhibitors

Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
Astemizole	1.7	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Cimetidine	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Clotrimazole	3.5	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Colchicine	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Cyclosporine	0.7	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Dexamethasone	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Digoxin	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
DPDE (enkephalin)	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Erythromycin	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Etoposide	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Hydrocortisone	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Itraconazole	0.7	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Ivermectin	0.5	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Ketoconazole	6.7	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Mibefradil	10	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Miconazole	2	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Midazolam	33	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Morphine	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Nicardipine	8	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Pimozide	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Quinidine	10	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Ranitidine	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Ritonavir	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Saquinavir	>50	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Terfenadine	2	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Verapamil	2	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
Vinblastine	8	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003

ND = not determined
1 denotes drugs that can potentially be used as in vitro substrates for studies of the transporter as defined by the FDA as of March 2022
2 denotes drugs that can potentially be used as in vitro inhibitors for studies of the transporter as defined by the FDA as of March 2022
3 denotes drugs that can potentially be used as clinical substrates for studies of the transporter as defined by the FDA as of March 2022
4 denotes drugs that can potentially be used as clinical inhibitors for studies of the transporter as defined by the FDA as of March 2022

Clinical Drug-Drug Interactions

No drug-drug interaction information.