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rat Slc22a3

Synonyms: Oct3

Entrez Gene Link

Expression Data
Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

Expression Data

Expression data for other tissues could be found in http://pharmacogenetics.ucsf.edu/gtex/index.html

No expression data.


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In Vitro Substrates

Substrate Km (μM) Cell System Reference
Dopamine 1500 HEK293-rOCT3 Amphoux, 2006
Epinephrine 1500 HEK293-rOCT3 Amphoux, 2006
Histamine 540 HEK293-rOCT3 Amphoux, 2006
Norepinephrine 1900 HEK293-rOCT3 Amphoux, 2006
Serotonin 500 HEK293-rOCT3 Amphoux, 2006

ND = not determined
1 denotes drugs that can potentially be used as in vitro substrates for studies of the transporter as defined by the FDA as of March 2022
2 denotes drugs that can potentially be used as in vitro inhibitors for studies of the transporter as defined by the FDA as of March 2022
3 denotes drugs that can potentially be used as clinical substrates for studies of the transporter as defined by the FDA as of March 2022
4 denotes drugs that can potentially be used as clinical inhibitors for studies of the transporter as defined by the FDA as of March 2022


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In Vitro Inhibitors

Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
3,4-methylenedioxymetamphetamine (MDMA) 1.6 N-methylpyridinium HEK293-rOCT3 Amphoux, 2006
Amantadine >1000 N-methylpyridinium HEK293-rOCT3 Amphoux, 2006
Cocaine >1000 N-methylpyridinium HEK293-rOCT3 Amphoux, 2006
D-amphetamine 4.5 N-methylpyridinium HEK293-rOCT3 Amphoux, 2006
Ketamine 65.7 N-methylpyridinium HEK293-rOCT3 Amphoux, 2006
Memantine 295 N-methylpyridinium HEK293-rOCT3 Amphoux, 2006
MK-801 >1000 N-methylpyridinium HEK293-rOCT3 Amphoux, 2006
Phencyclidine 3 N-methylpyridinium HEK293-rOCT3 Amphoux, 2006

ND = not determined
1 denotes drugs that can potentially be used as in vitro substrates for studies of the transporter as defined by the FDA as of March 2022
2 denotes drugs that can potentially be used as in vitro inhibitors for studies of the transporter as defined by the FDA as of March 2022
3 denotes drugs that can potentially be used as clinical substrates for studies of the transporter as defined by the FDA as of March 2022
4 denotes drugs that can potentially be used as clinical inhibitors for studies of the transporter as defined by the FDA as of March 2022


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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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