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rat Slc22a2

Synonyms: OCT2, OCT2r, rOCT2

Entrez Gene Link

Expression Data
Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

Expression Data

Expression data for other tissues could be found in http://pharmacogenetics.ucsf.edu/gtex/index.html

No expression data.


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In Vitro Substrates

Substrate Km (μM) Cell System Reference
Dopamine 2100 HEK293-rOCT2 Amphoux, 2006
Epinephrine 1370 HEK293-rOCT2 Amphoux, 2006
Histamine 890 HEK293-rOCT2 Amphoux, 2006
Norepinephrine 210 HEK293-rOCT2 Amphoux, 2006
Serotonin 460 HEK293-rOCT2 Amphoux, 2006

ND = not determined
1 denotes drugs that can potentially be used as in vitro substrates for studies of the transporter as defined by the FDA as of March 2022
2 denotes drugs that can potentially be used as in vitro inhibitors for studies of the transporter as defined by the FDA as of March 2022
3 denotes drugs that can potentially be used as clinical substrates for studies of the transporter as defined by the FDA as of March 2022
4 denotes drugs that can potentially be used as clinical inhibitors for studies of the transporter as defined by the FDA as of March 2022


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In Vitro Inhibitors

Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
3,4-methylenedioxymetamphetamine (MDMA) 2.77 N-methylpyridinium HEK293-rOCT2 Amphoux, 2006
Amantadine 81.9 N-methylpyridinium HEK293-rOCT2 Amphoux, 2006
Cocaine 23.8 N-methylpyridinium HEK293-rOCT2 Amphoux, 2006
D-amphetamine 4.7 N-methylpyridinium HEK293-rOCT2 Amphoux, 2006
Ketamine 207 N-methylpyridinium HEK293-rOCT2 Amphoux, 2006
Memantine 73 N-methylpyridinium HEK293-rOCT2 Amphoux, 2006
MK-801 >1000 N-methylpyridinium HEK293-rOCT2 Amphoux, 2006
Phencyclidine 16.1 N-methylpyridinium HEK293-rOCT2 Amphoux, 2006

ND = not determined
1 denotes drugs that can potentially be used as in vitro substrates for studies of the transporter as defined by the FDA as of March 2022
2 denotes drugs that can potentially be used as in vitro inhibitors for studies of the transporter as defined by the FDA as of March 2022
3 denotes drugs that can potentially be used as clinical substrates for studies of the transporter as defined by the FDA as of March 2022
4 denotes drugs that can potentially be used as clinical inhibitors for studies of the transporter as defined by the FDA as of March 2022


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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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