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OSTbeta

Synonyms: FLJ26090, MGC118959, MGC118960, MGC118961, OSTB

Entrez Gene Link

Expression Data
Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

Expression Data

Expression data for other tissues could be found in http://pharmacogenetics.ucsf.edu/gtex/index.html

Asterisk indicates important transporters in the organ as identified in the organ diagram.

Organ	Source	Relative Expression
Kidney*	Mean across all PMT Samples	`2.346`
Liver*	Mean across all PMT Samples	BLQ

Note that relative expression values should only be compared between entries of the same source.

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In Vitro Substrates

Substrate	Km (μM)	Cell System	Reference
Dehydroepiandrosterone sulfate	ND	OSTalpha-OSTbeta expressing oocytes	Ballatori, 2005
Digoxin	ND	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Estrone sulfate	320	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Prostaglandin E2	ND	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Taurocholate	ND	OSTalpha-OSTbeta expressing oocytes	Ballatori, 2005

ND = not determined
1 denotes drugs that can potentially be used as in vitro substrates for studies of the transporter as defined by the FDA as of March 2022
2 denotes drugs that can potentially be used as in vitro inhibitors for studies of the transporter as defined by the FDA as of March 2022
3 denotes drugs that can potentially be used as clinical substrates for studies of the transporter as defined by the FDA as of March 2022
4 denotes drugs that can potentially be used as clinical inhibitors for studies of the transporter as defined by the FDA as of March 2022

In Vitro Inhibitors

Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
Bilirubin ditaurate	>200	Estrone sulfate	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Digoxin	<500	Estrone sulfate	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Estrone sulfate	>200	Estrone sulfate	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Glycolithocholic acid	~200	Estrone sulfate	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Glycolithocholic acid sulfate	~200	Estrone sulfate	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Indomethacin	~200	Estrone sulfate	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Lithocholic acid sulfate	<200	Estrone sulfate	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Spironolactone	>200	Estrone sulfate	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Taurolithocholate	200	Estrone sulfate	OSTalpha-OSTbeta expressing oocytes	Seward, 2003
Taurolithocholic acid sulfate	<200	Estrone sulfate	OSTalpha-OSTbeta expressing oocytes	Seward, 2003

Clinical Drug-Drug Interactions

No drug-drug interaction information.