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ABCB4

Synonyms: ABC21, GBD1, MDR2, MDR2/3, MDR3, PFIC-3, PGY3

Entrez Gene Link

Expression Data
Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

Expression Data

Expression data for other tissues could be found in http://pharmacogenetics.ucsf.edu/gtex/index.html

Asterisk indicates important transporters in the organ as identified in the organ diagram.

Organ	Source	Relative Expression
Brain	Nishimura	`0.0000887`
Kidney	Nishimura	`0.000425`
Liver*	Nishimura	`0.150`
Placenta	Nishimura	`0.000122`
Small Intestine	Nishimura	`0.000614`
Kidney	Mean across all PMT Samples	BLQ
Liver*	Mean across all PMT Samples	`5.061`

Note that relative expression values should only be compared between entries of the same source.

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In Vitro Substrates

Substrate	Km (μM)	Cell System	Reference
Digoxin	ND	Nucleotide trapping assay with Sf9-MDR3 membranes	Smith, 2000
Paclitaxel	ND	Nucleotide trapping assay with Sf9-MDR3 membranes	Smith, 2000
Verapamil	ND	Nucleotide trapping assay with Sf9-MDR3 membranes	Smith, 2000
Vinblastine	ND	Nucleotide trapping assay with Sf9-MDR3 membranes	Smith, 2000

ND = not determined
1 denotes drugs that can potentially be used as in vitro substrates for studies of the transporter as defined by the FDA as of March 2022
2 denotes drugs that can potentially be used as in vitro inhibitors for studies of the transporter as defined by the FDA as of March 2022
3 denotes drugs that can potentially be used as clinical substrates for studies of the transporter as defined by the FDA as of March 2022
4 denotes drugs that can potentially be used as clinical inhibitors for studies of the transporter as defined by the FDA as of March 2022

In Vitro Inhibitors

Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
Cyclosporine	ND	Not applicable	nucleotide trapping with MDR3-expressing Sf9 membranes	Smith, 2000
Paclitaxel	ND	Not applicable	nucleotide trapping with MDR3-expressing Sf9 membranes	Smith, 2000
Valspodar	ND	Not applicable	nucleotide trapping with MDR3-expressing Sf9 membranes	Smith, 2000
Verapamil	ND	Not applicable	nucleotide trapping with MDR3-expressing Sf9 membranes	Smith, 2000
Vinblastine	ND	Not applicable	nucleotide trapping with MDR3-expressing Sf9 membranes	Smith, 2000

Clinical Drug-Drug Interactions

No drug-drug interaction information.