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Zaprinast

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC5 MRP5 Zaprinast 20 5-fluorodeoxyuridine monophosphate MRP5-expressing HEK293 vesicles Pratt, 2005
ABCC4 MRP4 Zaprinast 250 9-(2-phosphonomethoxyethyl)adenine (PMEA) MRP4-expressing HEK293 vesicles Reid, 2003
ABCC5 MRP5 Zaprinast 250 9-(2-phosphonomethoxyethyl)adenine (PMEA) MRP4-expressing HEK293 vesicles Reid, 2003
ABCC5 MRP5 Zaprinast 32.3 Carboxydichlorofluorescein MRP5-expressing HEK293 vesicles Pratt, 2006

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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