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Vincristine

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
ABCB1	MDR1, P-gp	3.7	ATPase assay of Sf9-MDR1 liposomes	Kimura, 2007

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
ABCB1	MDR1, P-gp	Vincristine	345		Calcein AM	Caco-2 cells	Eneroth, 2001
ABCB1	MDR1, P-gp	Vincristine		213	Digoxin	MDR1-expressing MDCK cells	Tang, 2002
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	Vincristine	44	42	Estradiol-17beta-glucuronide	HEK-OATP1B1	Karlgren, 2012
SLCO1B3	OATP1B3, OATP8	Vincristine	11	9.8	Estradiol-17beta-glucuronide	HEK293-OATP1B3	Karlgren, 2012
ABCC2	MRP2, cMOAT	Vincristine	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Vincristine	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Vincristine	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A5	OCTN2	Vincristine		15.9	L-carnitine	MDCKII-hOCTN2	Diao, 2010
ABCB11	BSEP	Vincristine	>133		Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
ABCB1	MDR1, P-gp	Vincristine	86		Verapamil	Caco-2 cells	Doppenshmitt, 1998
ABCC2	MRP2, cMOAT	Vincristine		802	Vinblastine	MDCK II-MRP2	Tang, 2002

No drug-drug interaction information.