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Valsartan

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLCO1B3	OATP1B3, OATP8	18.2	HEK293-OATP1B3	Kreel, 1991
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	1.39	HEK293-OATP1B1	Yamashiro, 2006
SLCO1B3	OATP1B3, OATP8	18.2	HEK293-OATP1B3	Yamashiro, 2006
ABCC2	MRP2, cMOAT	30.4	MRP2-expressing LLC-PK1 vesicles	Yamashiro, 2006
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	17.8	CHO-OATP1B1	Poirier, 2009
SLCO1B3	OATP1B3, OATP8	23.5	CHO-OATP1B3	Poirier, 2009
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	7.48	HEK-OATP1B1	Izumi, 2015
SLC22A8	OAT3	3.58	HEK293-OAT3	Hanna, 2018
SLC22A6	OAT1	4.72	HEK293-OAT1	Hanna, 2018

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
SLC22A8	OAT3	Valsartan	0.25		6-CF	COS-7-OAT3	Duan, 2012
SLC22A6	OAT1	Valsartan	1.97		Bestatin	HEK293-OAT1	Huo, 2014
SLC22A8	OAT3	Valsartan	0.36		Bestatin	HEK293-OAT3	Huo, 2014
SLC22A6	OAT1	Valsartan	14.8		Cidofovir	HEK293-OAT1	Hanna, 2018
ABCC2	MRP2, cMOAT	Valsartan	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Valsartan	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Valsartan	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A8	OAT3	Valsartan	1.11		Estrone sulfate	HEK293-OAT3	Hanna, 2018
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	Valsartan	14.98		Estrone sulfate	HEK-OATP1B1	Pei, 2018
SLC15A1	PEPT1	Valsartan		390	Glycylsarcosine	Caco-2	Knutter, 2009
SLC15A1	PEPT1	Valsartan		560	Glycylsarcosine	HeLa-PEPT1	Knutter, 2009
SLC15A2	PEPT2	Valsartan		110	Glycylsarcosine	HeLa-PEPT2	Knutter, 2009
SLC22A6	OAT1	Valsartan	9		Hydrochlorothiazide	HEK293-OAT1	Yin, 2019
SLC22A8	OAT3	Valsartan	2.3		Hydrochlorothiazide	HEK293-OAT3	Yin, 2019
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	Valsartan		8.96	Pitavastatin	HEK293-OATP1B1	Hirano, 2006
ABCB11	BSEP	Valsartan	>133		Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A11	OAT4	Valsartan	26		Uric acid	HEK293-OAT4	Sato, 2008
SLC22A6	OAT1	Valsartan	16		Uric acid	HEK293-OAT1	Sato, 2008
SLC22A8	OAT3	Valsartan	0.2		Uric acid	HEK293-OAT3	Sato, 2008

No drug-drug interaction information.