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Troleandomycin
Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions
No substrate information.
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* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
| Transporter |
Synonyms |
Inhibitor |
IC50 (μM) |
Ki (μM) |
Substrate used |
Cell System |
Reference |
| ABCB1 |
MDR1, P-gp |
Troleandomycin |
|
483.3 |
Calcein AM |
MDR1-expressing LLC-PK1 cells |
Ekins, 2002 |
| ABCB1 |
MDR1, P-gp |
Troleandomycin |
68.3 |
|
Daunorubicin |
NIH-3T3-G185 cells |
Wang, 2001 |
| ABCB1 |
MDR1, P-gp |
Troleandomycin |
78.2 |
|
LDS-751 |
NIH-3T3-G185 cells |
Wang, 2001 |
| ABCB1 |
MDR1, P-gp |
Troleandomycin |
86.3 |
|
Rhodamine 123 |
NIH-3T3-G185 cells |
Wang, 2001 |
| ABCB1 |
MDR1, P-gp |
Troleandomycin |
|
87.64 |
Vinblastine |
MDR1-expressing LLC-PK1 cells |
Ekins, 2002 |
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No drug-drug interaction information.
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