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Troglitazone

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Troglitazone 1.2 Estradiol-17beta-glucuronide CHO-OATP1B1 Gui, 2008
SLCO1B3 OATP1B3, OATP8 Troglitazone 15.7 Estradiol-17beta-glucuronide CHO-OATP1B3 Gui, 2008
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Troglitazone 1 Estradiol-17beta-glucuronide CHO-OATP1B1 Gui, 2009
ABCC3 MRP3 Troglitazone 31 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Troglitazone 61 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCB11 BSEP Troglitazone 16 Glycocholate BSEP-expressing Sf9 vesicles Kis, 2009
ABCB11 BSEP Troglitazone 27.6 Taurochenodeoxycholate BSEP-expressing Sf9 vesicles Kis, 2009
ABCB11 BSEP Troglitazone 9.5 Taurocholate BSEP-expressing Sf9 vesicles Kis, 2009
ABCB11 BSEP Troglitazone 3 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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