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Tetraethylammonium

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLC22A2	OCT2	76	OCT2-expressing oocytes	Gorboulev, 1997
SLC22A1	OCT1	229	HeLa-OCT1	Zhang, 1998
SLC22A2	OCT2	33.8	OCT2-expressing oocytes	Okuda, 1999
SLC22A4	OCTN1	195	OCTN1-expressing oocytes	Yabuuchi, 1999
SLC22A5	OCTN2	63	HRPE-hOCTN2	Wu, 1999
SLC22A5	OCTN2	215.7	HEK293-hOCTN2	Tamai, 2000
SLC47A1	MATE1	220	HEK293-MATE1	Otsuka, 2005
SLC47A2	MATE2K	830	HEK293-MATE2K	Masuda, 2006
SLC47A1	MATE1	380	HEK293-MATE1	Xie, 2007
SLC47A2	MATE2K	760	HEK293-MATE2K	Tanihara, 2007
SLC22A4	OCTN1	1800	HEK293-OCTN1	Urban, 2007
SLC22A1	OCT1	566	S2-OCT1	Iwai, 2009
SLC22A4	OCTN1	770	hOCTN1 reconstituted proteoliposome	Pochini, 2011
SLC22A1	OCT1	140	HEK293-OCT1	Hendrickx, 2013
SLC22A2	OCT2	71.9	CHO-OCT2	Severance, 2017
SLC22A2	OCT2	57.7	CHO-OCT2	Sandoval, 2018

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
SLC22A2	OCT2	Tetraethylammonium	77		1-methyl-4-phenylpyridinium (MPP+)	CHO-OCT2	Severance, 2017
SLC22A1	OCT1	Tetraethylammonium	7410		Ethidium	CHO-OCT1	Lee, 2009
SLC22A5	OCTN2	Tetraethylammonium		80	L-carnitine	HRPE-hOCTN2	Wu, 1999
SLC22A5	OCTN2	Tetraethylammonium	1200		L-carnitine	BeWo cells expressing OCTN2	Rytting, 2005
SLC22A5	OCTN2	Tetraethylammonium	132		L-carnitine	HEK293-hOCTN2	Kobayashi, 2007
SLC22A1	OCT1	Tetraethylammonium		158	N-methylpyridinium	OCT1-expressing oocytes	Dresser, 2000
SLC22A3	OCT3	Tetraethylammonium		1372	N-methylpyridinium	HRPE-OCT3	Wu, 2000
SLC22A1	OCT1	Tetraethylammonium	216		N-methylpyridinium	OCT1-expressing oocytes	Bourdet, 2005
SLC22A2	OCT2	Tetraethylammonium	222		N-methylpyridinium	OCT2-expressing oocytes	Bourdet, 2005
SLC22A3	OCT3	Tetraethylammonium	1237		N-methylpyridinium	OCT3-expressing oocytes	Bourdet, 2005
SLC22A1	OCT1	Tetraethylammonium	469.7		N-methylpyridinium	CHO-OCT1	Ming, 2009
SLC22A2	OCT2	Tetraethylammonium	189.2		N-methylpyridinium	CHO-OCT2	Ming, 2009
SLC22A3	OCT3	Tetraethylammonium	1476.6		N-methylpyridinium	CHO-OCT3	Ming, 2009
SLC22A2	OCT2	Tetraethylammonium	110		NBD-MTMA	CHO-OCT2	Belzer, 2013
rat_Slc47a1	MATE1	Tetraethylammonium	153		Paraquat	HEK293 cells	Chen, 2007
SLC47A1	MATE1	Tetraethylammonium	121		Paraquat	HEK293 cells	Chen, 2007
SLC22A1	OCT1	Tetraethylammonium	167		Tetraethylammonium	OCT1-expressing oocytes	Okuda, 1999
SLC22A4	OCTN1	Tetraethylammonium		439	Tetraethylammonium	HEK293-hOCTN1	Peltekova, 2004

No drug-drug interaction information.