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Tetracycline

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLC22A11 OAT4 122.7 S2-OAT4 Babu, 2002
SLC22A7 OAT2 439.9 S2-OAT2 Babu, 2002
SLC22A8 OAT3 566.2 S2-OAT3 Babu, 2002

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC2 MRP2, cMOAT Tetracycline >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Tetracycline >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Tetracycline >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCB11 BSEP Tetracycline >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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