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Tetrabromobisphenol A

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCB1 MDR1, P-gp Tetrabromobisphenol A 22.9 [3H]N-methylquinidine HEK293 cell membrane vesicles Dankers, 2013
SLC22A8 OAT3 Tetrabromobisphenol A 0.5 Estrone sulfate HEK293 cells Bruyere, 2017
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Tetrabromobisphenol A 0.6 Estrone sulfate CHO cells Bruyere, 2017
SLCO1B3 OATP1B3, OATP8 Tetrabromobisphenol A 12.1 Fluorescein CHO cells Bruyere, 2017
ABCC4 MRP4 Tetrabromobisphenol A 24 Methotrexate HEK293 cell membrane vesicles Dankers, 2013
SLC10A1 NTCP Tetrabromobisphenol A 4.5 Taurocholate HEK293 cells Bruyere, 2017
SLC22A1 OCT1 Tetrabromobisphenol A 37.5 Tetraethylammonium HEK293 cells Bruyere, 2017
SLC47A1 MATE1 Tetrabromobisphenol A 23.1 Tetraethylammonium HEK293 cells Bruyere, 2017

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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