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Tenofovir

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLC22A6 OAT1 33.8 CHO-OAT1 Cihlar, 2001
ABCC4 MRP4 >1000 MRP4-expressing HEK293 vesicles Imaoka, 2007

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Tenofovir 0.0009 1-methyl-4-phenylpyridinium (MPP+) CHO-OCT1 Minuesa, 2009
SLC22A1 OCT1 Tenofovir >10 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT1 Shen, 2017
SLC22A6 OAT1 Tenofovir 29.3 PAH HeLa-OAT1 Mandikova, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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