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Telmisartan

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLCO1B3	OATP1B3, OATP8	0.81	HEK293-OATP1B3	Ishiguro, 2006

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
SLC47A1	MATE1	Telmisartan	17.9		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-MATE1	Wittwer, 2013
SLC22A3	OCT3	Telmisartan	12		4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+)	HEK293-OCT3	Chen, 2022
SLC22A6	OAT1	Telmisartan	0.44		Bestatin	HEK293-OAT1	Huo, 2014
SLC22A8	OAT3	Telmisartan	1.38		Bestatin	HEK293-OAT3	Huo, 2014
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	Telmisartan		4.88	Cilostazol	HEK-OATP1B1	Wang, 2017
ABCC3	MRP3	Telmisartan	60		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Telmisartan	36		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC2	MRP2, cMOAT	Telmisartan	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A3	OCT3	Telmisartan	3.9		Metformin	HEK293-OCT3	Chen, 2022
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	Telmisartan		0.44	Pitavastatin	HEK293-OATP1B1	Hirano, 2006
ABCB11	BSEP	Telmisartan	16.2		Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A12	URAT1	Telmisartan		0.0182	Uric acid	URAT1-expressing oocytes	Iwanaga, 2007
ABCC4	MRP4	Telmisartan	11		Uric acid	MRP4-expressing Sf9 vesicles	Sato, 2008
SLC22A11	OAT4	Telmisartan	1.2		Uric acid	HEK293-OAT4	Sato, 2008
SLC22A6	OAT1	Telmisartan	0.46		Uric acid	HEK293-OAT1	Sato, 2008
SLC22A8	OAT3	Telmisartan	1.6		Uric acid	HEK293-OAT3	Sato, 2008

No drug-drug interaction information.