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Taurocholate

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLCO1A2	OATP1A2, OATP-A	60	OATP1A2-expressing oocytes	Kullak-Ublick, 1995
SLC10A2	ASBT, SBAT2	13.3	COS1-ASBT	Craddock, 1998
SLC10A1	NTCP	7.9	HeLa-NTCP	Kim, 1999
SLCO1B3	OATP1B3, OATP8	5.8	OATP1B3-expressing oocytes	Abe, 2001
SLC10A2	ASBT, SBAT2	16	COS-ASBT	Love, 2001
SLC10A2	ASBT, SBAT2	9.4	HEK-ASBT	Hallen, 2002
ABCC3	MRP3	30	MRP3-expressing HEK293 vesicles	Zhang, 2003
SLCO2B1	OATP2B1, OATP-B	71.8	HEK293-OATP2B1	Nozawa, 2004
SLC10A1	NTCP	7.5	HeLa-NTCP	Ho, 2004
ABCB11	BSEP	4.64	BSEP-expressing HEK293 vesicles	Hirano, 2005
OSTalpha	OSTA	ND	OSTalpha-OSTbeta expressing oocytes	Ballatori, 2005
OSTbeta	OSTB	ND	OSTalpha-OSTbeta expressing oocytes	Ballatori, 2005
SLC10A1	NTCP	2.1	HEK-NTCP	Leslie, 2007
ABCB11	BSEP	15	Sf9-BSEP	Kis, 2009
mouse_Slco1a4	Oat, Oatp2, Oatp1a4, Slc21a5	40.3	HEK293 cells	Ose, 2010

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
ABCC3	MRP3	Taurocholate	40		Estradiol-17beta-glucuronide	MRP3-expressing HEK293 vesicles	Zhang, 2003
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	Taurocholate		11.4	Estradiol-17beta-glucuronide	CHO-OATP1B1	Gui, 2009

No drug-drug interaction information.