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Sulindac

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A8 OAT3 Sulindac 1.65 6-carboxyfluorescein HEK293-OAT3 Zou, 2021
SLC22A6 OAT1 Sulindac 56.8 6-carboxyfluorescein HEK293-OAT1 Zou, 2021
ABCC3 MRP3 Sulindac >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Sulindac >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A11 OAT4 Sulindac 617 Estrone sulfate S2-OAT4 Khamdang, 2002
SLC22A8 OAT3 Sulindac 3.62 Estrone sulfate S2-OAT3 Khamdang, 2002
ABCC4 MRP4 Sulindac 2.11 Methotrexate MRP4-expressing HEK293 vesicles El-Sheikh, 2007
SLC22A6 OAT1 Sulindac 36.2 Para-aminohippurate S2-OAT1 Khamdang, 2002
SLC22A7 OAT2 Sulindac 440 Prostaglandin F2-alpha S2-OAT2 Khamdang, 2002
ABCB11 BSEP Sulindac >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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