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Sulfinpyrazone

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC4 MRP4 Sulfinpyrazone 420 9-(2-phosphonomethoxyethyl)adenine (PMEA) MRP4-expressing HEK293 vesicles Reid, 2003
ABCC5 MRP5 Sulfinpyrazone 300 9-(2-phosphonomethoxyethyl)adenine (PMEA) MRP4-expressing HEK293 vesicles Reid, 2003
ABCC5 MRP5 Sulfinpyrazone 103.2 Carboxydichlorofluorescein MRP5-expressing HEK293 vesicles Pratt, 2006
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Sulfinpyrazone 32 Estradiol-17beta-glucuronide HEK-OATP1B1 Yoshida, 2012
SLC22A12 URAT1 Sulfinpyrazone ~100 Uric acid HEK293-URAT1 Yu, 2007

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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