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SN-38

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
ABCC2 MRP2, cMOAT 180 bile canalicular membrane vesicles Chu, 1998
ABCG2 BCRP, MXR 4 BCRP-expressing PC-6/SN2-5H vesicles Nakatomi, 2001

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCG2 BCRP, MXR SN-38 1.6 Estrone sulfate BCRP-expressing vesicles from mouse lymphoma (P388) cells Suzuki, 2003

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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