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Simvastatin lactone

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCB1 MDR1, P-gp Simvastatin lactone 10 Calcein AM MDR1 expressing MDCK cells Chen, 2005
ABCC2 MRP2, cMOAT Simvastatin lactone 25 Calcein AM MRP2-expressing MDCK cells Chen, 2005
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Simvastatin lactone 9.7 Estradiol-17beta-glucuronide HEK-OATP1B1 Chen, 2005

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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