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Silibinin dihemisuccinate

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLCO1B3 OATP1B3, OATP8 Silibinin dihemisuccinate 0.4 Amanitin MDCK II-OATP1B3 Letschert, 2006
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Silibinin dihemisuccinate 10 Bromsulphthalein MDCK II-OATP1B1 Letschert, 2006
SLCO1B3 OATP1B3, OATP8 Silibinin dihemisuccinate 1 Bromsulphthalein MDCK II-OATP1B3 Letschert, 2006
SLCO2B1 OATP2B1, OATP-B Silibinin dihemisuccinate 1 Bromsulphthalein MDCK II-OATP2B1 Letschert, 2006

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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