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Sacubitril

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Sacubitril 1.91 Estradiol-17beta-glucuronide HEK-OATP1B1 Ayalasomayajula, 2016
SLCO1B3 OATP1B3, OATP8 Sacubitril 3.81 Estradiol-17beta-glucuronide HEK293-OATP1B3 Ayalasomayajula, 2016
SLC22A8 OAT3 Sacubitril 0.795 Estrone sulfate HEK293-OAT3 Hanna, 2018

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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