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Roxithromycin

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Roxithromycin 153 Bromsulphthalein HEK-OATP1B1 Seithel, 2007
SLCO1B3 OATP1B3, OATP8 Roxithromycin 37 Bromsulphthalein HEK293-OATP1B3 Seithel, 2007
ABCB1 MDR1, P-gp Roxithromycin 15.4 Digoxin Caco-2 cells Eberl, 2007
ABCC2 MRP2, cMOAT Roxithromycin >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Roxithromycin >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Roxithromycin >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A5 OCTN2 Roxithromycin 333 L-carnitine MDCKII-hOCTN2 Diao, 2010
ABCB11 BSEP Roxithromycin >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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