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Reserpine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCB1 MDR1, P-gp Reserpine 2.6 Calcein AM NIH-3T3-G185 cells Wang, 2001
ABCB1 MDR1, P-gp Reserpine 12.2 Calcein AM MDR1-expressing LLC-PK1 cells Ekins, 2002
ABCB1 MDR1, P-gp Reserpine 3.2 Calcein AM MDR1 expressing A2780/ADR cells Muller, 2007
ABCB1 MDR1, P-gp Reserpine 0.5 Daunorubicin NIH-3T3-G185 cells Wang, 2001
SLCO2B1 OATP2B1, OATP-B Reserpine 3.5 Dibromofluorescein HEK293-OATP2B1 Unger, 2020
ABCB1 MDR1, P-gp Reserpine 1.38 Digoxin Caco-2 Tang, 2002
ABCB1 MDR1, P-gp Reserpine 11.5 Digoxin MDCK-MDR1 Tang, 2002
ABCB1 MDR1, P-gp Reserpine 2.31 Digoxin MDR1-expressing Caco-2 cells Horie, 2003
ABCC2 MRP2, cMOAT Reserpine 68.4 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Reserpine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Reserpine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCB1 MDR1, P-gp Reserpine 2.1 Fluo-3 NIH-3T3-G185 cells Wang, 2001
ABCB1 MDR1, P-gp Reserpine 3.2 Hoechst 33342 MDR1 expressing A2780/ADR cells Pick, 2008
ABCB1 MDR1, P-gp Reserpine 6.1 JC-1 NIH-3T3-G185 cells Wang, 2001
SLC22A5 OCTN2 Reserpine 32.2 L-carnitine MDCKII-hOCTN2 Diao, 2010
ABCB1 MDR1, P-gp Reserpine 2.1 LDS-751 NIH-3T3-G185 cells Wang, 2001
ABCB1 MDR1, P-gp Reserpine 3.9 Rhodamine 123 NIH-3T3-G185 cells Wang, 2001
ABCB11 BSEP Reserpine 2.8 Taurocholate Sf9-BSEP Kis, 2009
ABCB11 BSEP Reserpine 8.35 Taurocholate Sf9 cell membrane vesicles Morgan, 2013
ABCB1 MDR1, P-gp Reserpine 5.3 Tetramethylrosamine NIH-3T3-G185 cells Wang, 2001
ABCB1 MDR1, P-gp Reserpine 0.97 Vinblastine MDR1-expressing LLC-PK1 cells Ekins, 2002
ABCC2 MRP2, cMOAT Reserpine 295 Vinblastine MDCK II-MRP2 Tang, 2002

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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