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Rabeprazole

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC2 MRP2, cMOAT Rabeprazole >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Rabeprazole >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Rabeprazole >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A1 OCT1 Rabeprazole 3 Metformin HEK293-OCT1 Nies, 2011
SLC22A2 OCT2 Rabeprazole 5.7 Metformin HEK293-OCT2 Nies, 2011
ABCG2 BCRP, MXR Rabeprazole 8.5 Methotrexate BCRP membrane vesicles Suzuki, 2009
SLC22A8 OAT3 Rabeprazole 4.8 Methotrexate HEK293-OAT3 Narumi, 2017
ABCB11 BSEP Rabeprazole 33.9 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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