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Propranolol

In Vitro Substrates

No substrate information.

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
SLC22A1	OCT1	Propranolol	113	1-methyl-4-phenylpyridinium (MPP+)	HEK293-OCT1	Umehara, 2008
SLC22A1	OCT1	Propranolol	1.3	1-methyl-4-phenylpyridinium (MPP+)	MDCK-OCT1	Grube, 2011
SLC47A1	MATE1	Propranolol	7.81	1-methyl-4-phenylpyridinium (MPP+)	CHO-MATE1	Astorga, 2012
SLC47A2	MATE2K	Propranolol	7.71	1-methyl-4-phenylpyridinium (MPP+)	CHO-MATE2K	Astorga, 2012
SLC22A2	OCT2	Propranolol	71.6	1-methyl-4-phenylpyridinium (MPP+)	CHO-OCT2	Belzer, 2013
ABCB1	MDR1, P-gp	Propranolol	429	Calcein AM	Caco-2 cells	Eneroth, 2001
ABCC2	MRP2, cMOAT	Propranolol	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Propranolol	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Propranolol	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A2	OCT2	Propranolol	229	N-methylpyridinium	HEK293-OCT2	Zolk, 2009
SLC22A2	OCT2	Propranolol	67.2	NBD-MTMA	CHO-OCT2	Belzer, 2013
SLC22A1	OCT1	Propranolol	6.2	Sumatriptan	HEK293-OCT1	Matthaei, 2016
ABCB11	BSEP	Propranolol	>133	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
ABCB1	MDR1, P-gp	Propranolol	350	Verapamil	Caco-2 cells	Doppenshmitt, 1998

No drug-drug interaction information.