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Propafenone

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Propafenone 1 1-methyl-4-phenylpyridinium (MPP+) MDCK-OCT1 Grube, 2011
SLC22A1 OCT1 Propafenone 14.1 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT1 Ahlin, 2010
SLC22A1 OCT1 Propafenone 15.54 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT1 Chen, 2017
ABCB1 MDR1, P-gp Propafenone 0.3 Daunorubicin MDR1 exressing CCRF-cEM/VCR 1000 cells Jabeen, 2012
ABCC2 MRP2, cMOAT Propafenone >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Propafenone >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Propafenone >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A5 OCTN2 Propafenone 74.2 L-carnitine MDCKII-hOCTN2 Diao, 2010
SLC22A2 OCT2 Propafenone 25 N-methylpyridinium HEK293-OCT2 Zolk, 2009
SLC22A2 OCT2 Propafenone 3.6 NBD-MTMA CHO-OCT2 Belzer, 2013
ABCB11 BSEP Propafenone >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013
SLC22A4 OCTN1 Propafenone 67.5 Tetraethylammonium MDCKII-hOCTN1 Grube, 2011

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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