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Proguanil

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLC22A1 OCT1 8.1 HEK293-OCT1 van, 2017
SLC22A2 OCT2 9 HEK293-OCT2 van, 2017
SLC22A1 OCT1 17.7 HEK293-OCT1 Matthaei, 2019

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC47A1 MATE1 Proguanil 4.35 1-methyl-4-phenylpyridinium (MPP+) CHO-MATE1 Astorga, 2012
SLC47A2 MATE2K Proguanil 1.39 1-methyl-4-phenylpyridinium (MPP+) CHO-MATE2K Astorga, 2012
SLC22A2 OCT2 Proguanil 13 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT2 van, 2017

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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