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Progesterone

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
ABCB1	MDR1, P-gp	30	MDR1-containing proteoliposomes	Borgnia, 1996

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
SLC22A1	OCT1	Progesterone	3.05		1-methyl-4-phenylpyridinium (MPP+)	HEK293-OCT1	Hayer-Zillgen, 2002
ABCB1	MDR1, P-gp	Progesterone	121		Calcein AM	Caco-2 cells	Eneroth, 2001
ABCB1	MDR1, P-gp	Progesterone	47.9		Calcein AM	MDR1 expressing A2780/ADR cells	Muller, 2007
ABCB1	MDR1, P-gp	Progesterone	96.2		Daunorubicin	NIH-3T3-G185 cells	Wang, 2001
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	Progesterone	5.4		Fluorescein-Methotrexate	CHO-OATP1B1	Gui, 2010
ABCB1	MDR1, P-gp	Progesterone	47.9		Hoechst 33342	MDR1 expressing A2780/ADR cells	Pick, 2008
SLC22A5	OCTN2	Progesterone		48.6	L-carnitine	BeWo cells expressing OCTN2	Rytting, 2008
ABCB1	MDR1, P-gp	Progesterone	88.1		LDS-751	NIH-3T3-G185 cells	Wang, 2001
ABCB1	MDR1, P-gp	Progesterone	192.2		Rhodamine 123	NIH-3T3-G185 cells	Wang, 2001

No drug-drug interaction information.