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Prochlorperazine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Prochlorperazine 49.6 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT1 Ahlin, 2008
ABCC2 MRP2, cMOAT Prochlorperazine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Prochlorperazine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Prochlorperazine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A5 OCTN2 Prochlorperazine 51.3 L-carnitine MDCKII-hOCTN2 Diao, 2009
SLC47A1 MATE1 Prochlorperazine 7.9 Metformin CHO-MATE1 Martinez-Guerrero, 2016
ABCB11 BSEP Prochlorperazine >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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