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Prazosin

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
ABCB1 MDR1, P-gp 20 MDR1-expressing insect vesicles Dey, 1997

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Prazosin 1.84 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT1 Hayer-Zillgen, 2002
SLC22A1 OCT1 Prazosin 9.9 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT1 Ahlin, 2008
SLC22A1 OCT1 Prazosin 50.9 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT1 Ahlin, 2010
SLC22A2 OCT2 Prazosin 13.6 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-OCT2 Wittwer, 2013
SLC47A1 MATE1 Prazosin 1.6 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-MATE1 Wittwer, 2013
SLC47A2 MATE2K Prazosin 38.4 4-(4-dimethylamino)styryl-N-methylpyridinium (ASP+) HEK293-MATE2K Wittwer, 2013
ABCC4 MRP4 Prazosin 12.5 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Prazosin >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A8 OAT3 Prazosin 29.84 Estrone sulfate HEK293-OAT3 Burckhardt, 2017
SLC22A1 OCT1 Prazosin 1.8 Metformin HEK293-OCT1 Yee, 2021
ABCG2 BCRP, MXR Prazosin 10 Methotrexate BCRP membrane vesicles Saito, 2006
SLC22A3 OCT3 Prazosin 12.6 N-methylpyridinium HEK293-OCT2 Hayer-Zillgen, 2002
SLC22A6 OAT1 Prazosin 4.89 PAH HEK293-OAT1 Burckhardt, 2017
ABCB11 BSEP Prazosin >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013
SLC22A1 OCT1 Prazosin 2.3 Tetraethylammonium KCL22-OCT1 Moss, 2015
SLC22A1 OCT1 Prazosin 1.56 YM155 HEK293-OCT1 Minematsu, 2010
SLC22A2 OCT2 Prazosin 80.4 YM155 HEK293-OCT2 Minematsu, 2010

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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