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Pioglitazone

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A8 OAT3 Pioglitazone 1.02 6-carboxyfluorescein HEK293-OAT3 Zou, 2021
SLC22A6 OAT1 Pioglitazone 6.3 6-carboxyfluorescein HEK293-OAT1 Zou, 2021
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Pioglitazone 39.6 Cerivastatin HEK-OATP1B1 Tamraz, 2013
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Pioglitazone 5.09 Estradiol-17beta-glucuronide HEK-OATP1B1 van, 2013
ABCC4 MRP4 Pioglitazone 49.5 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Pioglitazone >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Pioglitazone 6.8 Estrone sulfate HEK-OATP1B1 Tamraz, 2013
SLC22A1 OCT1 Pioglitazone 185 Metformin HEK293-OCT1 Ahlin, 2010
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Pioglitazone 32.2 Rosuvastatin HEK-OATP1B1 van, 2013
ABCB11 BSEP Pioglitazone 0.4 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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