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Phenformin

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLC22A2 OCT2 37.4 OCT2-expressing oocytes Sogame, 2013

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCC2 MRP2, cMOAT Phenformin >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Phenformin >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Phenformin >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A1 OCT1 Phenformin 13 N-methylpyridinium HEK293-OCT1 Umehara, 2007
SLC22A2 OCT2 Phenformin 54 N-methylpyridinium HEK293-OCT2 Umehara, 2007
SLC22A3 OCT3 Phenformin 134 N-methylpyridinium HEK293-OCT3 Umehara, 2007
ABCB11 BSEP Phenformin >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013
SLC22A1 OCT1 Phenformin 23 Tetraethylammonium HEK293-OCT1 Umehara, 2007
SLC22A2 OCT2 Phenformin 111 Tetraethylammonium HEK293-OCT2 Umehara, 2007

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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