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Perfluorooctanoic acid

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLC22A6 OAT1 48 HEK293 cells Nakagawa, 2008
SLC22A8 OAT3 49.1 HEK293 cells Nakagawa, 2008
rat_Slc22a6 Oat1, Paht, Roat1, Orctl1 51 HEK293 cells Nakagawa, 2008
rat_Slc22a8 Oat3, Roct 80.2 HEK293 cells Nakagawa, 2008

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
rat_Slco1a1 Oatp1, OATP-1, Slc21a1, Slc21a3 Perfluorooctanoic acid - 83.8 Estrone sulfate CHO cells Yang, 2009
mouse_Abcb1a Mdr, Pgp, Pgy, Mdr3, P-gp, Abcb4, Mdr1a Perfluorooctanoic acid 156.5 Verapamil Purified, detergent-solubilized protein Nicklisch, 2016

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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