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Pemetrexed

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
ABCC5	MRP5	281	MRP5-expressing HEK293 vesicles	Pratt, 2006
ABCG2	BCRP, MXR	390	Membrane vesicles	Li, 2011
SLCO2B1	OATP2B1, OATP-B	300	OATP2B1-expressing oocytes	Visentin, 2012
SLCO2B1	OATP2B1, OATP-B	348	OATP2B1-expressing HeLa R1-11	Visentin, 2012
SLC22A8	OAT3	28.2	HEK293-OAT3	Kurata, 2014

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
ABCC5	MRP5	Pemetrexed	2110		5-fluorodeoxyuridine monophosphate	MRP5-expressing HEK293 vesicles	Pratt, 2005
ABCC5	MRP5	Pemetrexed	442		Carboxydichlorofluorescein	MRP5-expressing HEK293 vesicles	Pratt, 2006
ABCC5	MRP5	Pemetrexed		300	Carboxydichlorofluorescein	MRP5-expressing HEK293 vesicles	Pratt, 2006

No drug-drug interaction information.