UCSF home page | About UCSF | UCSF Medical Center

Skip to TransPortal content

Enlarge Text
Click to increase the text size. Restore Text
Click to restore original text size. Reduce Text
Click to decrease the text size.


Decrease the text size \| Restore text size \| Increase the text size

Para-Aminosalicylic acid (PAS)

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	50	HEK-OATP1B1	Parvez, 2017
SLC22A6	OAT1	78	HEK293-OAT1	Parvez, 2017
SLC22A8	OAT3	100	HEK293-OAT3	Parvez, 2017
SLC22A2	OCT2	28.7	HEK293-OCT2	Parvez, 2017

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
SLC22A2	OCT2	Para-Aminosalicylic acid (PAS)	94.2	1-methyl-4-phenylpyridinium (MPP+)	HEK293-OCT2	Parvez, 2016
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	Para-Aminosalicylic acid (PAS)	72.6	Estrone sulfate	HEK-OATP1B1	Parvez, 2016
SLC22A8	OAT3	Para-Aminosalicylic acid (PAS)	24.6	Estrone sulfate	HEK293-OAT3	Parvez, 2016
SLC22A2	OCT2	Para-Aminosalicylic acid (PAS)	85.8	Metformin	HEK293-OCT2	Parvez, 2016
SLC22A6	OAT1	Para-Aminosalicylic acid (PAS)	37.6	PAH	HEK293-OAT1	Parvez, 2016

No drug-drug interaction information.