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Para-aminohippurate

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLC22A6	OAT1	9.3	OAT1-expressing oocytes	Hosoyamada, 1999
SLC22A6	OAT1	5	HeLa-OAT1	Lu, 1999
SLC22A6	OAT1	4	OAT1-expressing oocytes	Cihlar, 1999
SLC22A6	OAT1	15.4	CHO-OAT1	Ho, 2000
ABCC1	MRP1	372	MRP1-expressing HeLa vesicles	Leier, 2000
ABCC2	MRP2, cMOAT	880	MRP2-expressing HEK293 vesicles	Leier, 2000
SLC22A6	OAT1	15.4	CHO-OAT1	Cihlar, 2000
SLC22A8	OAT3	87.2	OAT3-expressing oocytes	Cha, 2001
SLC22A6	OAT1	20.1	S2-OAT1	Takeda, 2001
SLC22A6	OAT1	3.9	OAT1-expressing oocytes	Islinger, 2001
ABCC4	MRP4	160	MRP4-expressing Sf9 vesicles	Smeets, 2004
ABCC2	MRP2, cMOAT	2100	MRP2-expressing MDCK II vesicles	Smeets, 2004
ABCC2	MRP2, cMOAT	5000	MRP2-expressing Sf9 vesicles	Smeets, 2004
SLC22A6	OAT1	28	HEK293-OAT1	Ueo, 2005
SLC22A6	OAT1	28	HEK293 cells	Ueo, 2005

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
SLC22A6	OAT1	Para-aminohippurate	8.8		6-carboxyfluorescein	CHO-OAT1	Cihlar, 2000
SLC22A6	OAT1	Para-aminohippurate	106	92	Bestatin	HEK293-OAT1	Zhu, 2012
SLC22A6	OAT1	Para-aminohippurate		6.02	Ochratoxin A	S2-OAT1	Jung, 2001
SLC22A8	OAT3	Para-aminohippurate		19.6	Ochratoxin A	S2-OAT2	Jung, 2001

No drug-drug interaction information.