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Omeprazole

In Vitro Substrates

No substrate information.

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
ABCC2	MRP2, cMOAT	Omeprazole	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Omeprazole	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Omeprazole	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A5	OCTN2	Omeprazole		5.2	L-carnitine	hOCTN2-reconstituted proteoliposomes	Pochini, 2009
SLC22A1	OCT1	Omeprazole	15.7		Metformin	HEK293-OCT1	Nies, 2011
SLC22A2	OCT2	Omeprazole	6.7		Metformin	HEK293-OCT2	Nies, 2011
SLC47A1	MATE1	Omeprazole	16.1		Metformin	CHO-MATE1	Martinez-Guerrero, 2016
ABCG2	BCRP, MXR	Omeprazole	17		Methotrexate	BCRP membrane vesicles	Suzuki, 2009
SLC22A8	OAT3	Omeprazole	5.5		Methotrexate	HEK293-OAT3	Narumi, 2017
SLC22A2	OCT2	Omeprazole	5.53		Para-Aminosalicylic acid (PAS)	HEK293-OCT2	Parvez, 2017
SLC22A6	OAT1	Omeprazole	1.76		Para-Aminosalicylic acid (PAS)	HEK293-OAT1	Parvez, 2017
SLC22A8	OAT3	Omeprazole	5.1		Para-Aminosalicylic acid (PAS)	HEK293-OAT3	Parvez, 2017
ABCB11	BSEP	Omeprazole	99		Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013

No drug-drug interaction information.