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Olmesartan

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	42.6	OATP1B1-expressing oocytes	Nakagomi-Hagihara, 2006
SLCO1B3	OATP1B3, OATP8	71.8	OATP1B3-expressing oocytes	Nakagomi-Hagihara, 2006
SLC22A6	OAT1	0.0683	HEK293-OAT1	Yamada, 2007
SLC22A8	OAT3	0.12	HEK293-OAT3	Yamada, 2007
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	12.8	HEK293-OATP1B1	Yamada, 2007
ABCC2	MRP2, cMOAT	14.9	MRP2-expressing LLC-PK1 vesicles	Yamada, 2007
ABCC4	MRP4	26.2	MRP4-expressing LLC-PK1 vesicles	Yamada, 2007
SLCO1B3	OATP1B3, OATP8	44.2	HEK293-OATP1B3	Yamada, 2007

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
SLCO2B1	OATP2B1, OATP-B	Olmesartan	4.71	Dibromofluorescein	HEK293-OATP2B1	Unger, 2020
ABCC3	MRP3	Olmesartan	2	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Olmesartan	28.5	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCB11	BSEP	Olmesartan	4.73	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A11	OAT4	Olmesartan	4.4	Uric acid	HEK293-OAT4	Sato, 2008
SLC22A6	OAT1	Olmesartan	0.28	Uric acid	HEK293-OAT1	Sato, 2008
SLC22A8	OAT3	Olmesartan	0.027	Uric acid	HEK293-OAT3	Sato, 2008

No drug-drug interaction information.