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Olaparib

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A2 OCT2 Olaparib 19.9 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT2 McCormick, 2017
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Olaparib 20.3 Estradiol-17beta-glucuronide HEK-OATP1B1 McCormick, 2017
SLC22A8 OAT3 Olaparib 18.4 Furosemide HEK293-OAT3 McCormick, 2017
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Olaparib 27.1 Pravastatin HEK-OATP1B1 McCormick, 2017

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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