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Novobiocin

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLCO2B1 OATP2B1, OATP-B Novobiocin 3.4 Dibromofluorescein HEK293-OATP2B1 Unger, 2020
SLC22A11 OAT4 Novobiocin 92.68 90.5 Estrone sulfate COS7-OAT4 Duan, 2009
SLC22A8 OAT3 Novobiocin 4.99 4.77 Estrone sulfate COS7-OAT3 Duan, 2009
SLC22A6 OAT1 Novobiocin 34.8 14.9 Para-aminohippurate COS7-OAT1 Duan, 2009
ABCG2 BCRP, MXR Novobiocin 1.4 Rosuvastatin polarized Caco-2 monolayer Elsby, 2016

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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