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Nisoldipine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
ABCB1 MDR1, P-gp Nisoldipine 44.1 Digoxin MDR1 expressing LLC-PK1 cells Takara, 2002
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Nisoldipine 7.4 Estradiol-17beta-glucuronide HEK-OATP1B1 Yoshida, 2012
ABCC4 MRP4 Nisoldipine 16.5 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC2 MRP2, cMOAT Nisoldipine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Nisoldipine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCB11 BSEP Nisoldipine 33 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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