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Nilotinib

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLCO1B3 OATP1B3, OATP8 7.84 HEK293-OATP1B3 McFeely, 2019

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Nilotinib 91 1-methyl-4-phenylpyridinium (MPP+) HEK293-OCT1 Johnston, 2014
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 Nilotinib 2.78 Estrone sulfate CHO-OATP1B1 Khurana, 2014
SLC22A8 OAT3 Nilotinib 0.41 Estrone sulfate HEK293-OAT3 Johnston, 2014
SLC22A1 OCT1 Nilotinib 2.92 Metformin HEK293-OCT1 Minematsu, 2011
ABCG2 BCRP, MXR Nilotinib 0.69 Methotrexate BCRP-expressing HEK293 vesicles Tiwari, 2009

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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