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Nifedipine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

No substrate information.


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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A1 OCT1 Nifedipine 31.1 1-methyl-4-phenylpyridinium (MPP+) MDCK-OCT1 Grube, 2011
ABCB1 MDR1, P-gp Nifedipine 113 Daunorubicin NIH-G185 cells Wang, 2001
ABCB1 MDR1, P-gp Nifedipine 472 Digoxin MDR1 expressing LLC-PK1 cells Takara, 2002
ABCC4 MRP4 Nifedipine 16.6 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC2 MRP2, cMOAT Nifedipine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC3 MRP3 Nifedipine >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
SLC22A5 OCTN2 Nifedipine 59.4 L-carnitine MDCKII-hOCTN2 Grube, 2011
ABCG2 BCRP, MXR Nifedipine 10.7 Rosuvastatin polarized Caco-2 monolayer Elsby, 2016
ABCB11 BSEP Nifedipine 64 Taurocholate Sf9 cell membrane vesicles Morgan, 2013
SLC22A4 OCTN1 Nifedipine 74.6 Tetraethylammonium MDCKII-hOCTN1 Grube, 2011
ABCB1 MDR1, P-gp Nifedipine 73 Vinblastine F4-6P cells Hollt, 1992
grivet_ABCB1 p-glycoprotein Nifedipine 74 Vinblastine COS-7 cells Hollt, 1992

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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