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Nicardipine

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Km (μM)	Cell System	Reference
ABCB1	MDR1, P-gp	2.6	ATPase assay of Sf9-MDR1 liposomes	Kimura, 2007

In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
ABCB1	MDR1, P-gp	Nicardipine	6.6	Calcein AM	NIH-3T3-G185 cells	Wang, 2001
ABCB1	MDR1, P-gp	Nicardipine	2.3	Calcein AM	MDR1 expressing LLC-PK1 cells	Schwab, 2003
mouse_Abcb1a	Mdr, Pgp, Pgy, Mdr3, P-gp, Abcb4, Mdr1a	Nicardipine	2.5	Calcein AM	Mouse mdr1a expressing LLC-PK1 cells	Schwab, 2003
mouse_Abcb1b	mdr, Mdr1, Pgy1, Abcb1, Mdr1b, Pgy-1	Nicardipine	8	Calcein AM	Mouse mdr1b expressing LLC-PK1 cells	Schwab, 2003
ABCB1	MDR1, P-gp	Nicardipine	4.8	Calcein AM	MDR1 expressing A2780/ADR cells	Muller, 2007
ABCB1	MDR1, P-gp	Nicardipine	17.5	Daunorubicin	MDR1 expressing LLC-PK1 cells	Katoh, 2000
ABCB1	MDR1, P-gp	Nicardipine	3.2	Daunorubicin	NIH-3T3-G185 cells	Wang, 2001
ABCB1	MDR1, P-gp	Nicardipine	4.5	Digoxin	MDR1 expressing LLC-PK1 cells	Takara, 2002
ABCC4	MRP4	Nicardipine	88	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC2	MRP2, cMOAT	Nicardipine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Nicardipine	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCB1	MDR1, P-gp	Nicardipine	14.6	Fluo-3	NIH-3T3-G185 cells	Wang, 2001
ABCB1	MDR1, P-gp	Nicardipine	4.8	Hoechst 33342	MDR1 expressing A2780/ADR cells	Pick, 2008
ABCB1	MDR1, P-gp	Nicardipine	7.1	JC-1	NIH-3T3-G185 cells	Wang, 2001
ABCB1	MDR1, P-gp	Nicardipine	5.6	LDS-751	NIH-3T3-G185 cells	Wang, 2001
ABCB1	MDR1, P-gp	Nicardipine	25.8	Rhodamine 123	NIH-3T3-G185 cells	Wang, 2001
ABCB11	BSEP	Nicardipine	7.87	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
ABCB1	MDR1, P-gp	Nicardipine	11.7	Tetramethylrosamine	NIH-3T3-G185 cells	Wang, 2001

Clinical Drug-Drug Interactions

No drug-drug interaction information.