UCSF home page | About UCSF | UCSF Medical Center

Skip to TransPortal content

Enlarge Text
Click to increase the text size. Restore Text
Click to restore original text size. Reduce Text
Click to decrease the text size.


Decrease the text size \| Restore text size \| Increase the text size

Nelfinavir

In Vitro Substrates

No substrate information.

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Ki (μM)	Substrate used	Cell System	Reference
SLC22A1	OCT1	Nelfinavir	7		1-methyl-4-phenylpyridinium (MPP+)	HEK293-OCT1	Jung, 2008
ABCB1	MDR1, P-gp	Nelfinavir	3.4		Calcein AM	MDR1 expressing LLC-PK1 cells	Schwab, 2003
mouse_Abcb1a	Mdr, Pgp, Pgy, Mdr3, P-gp, Abcb4, Mdr1a	Nelfinavir	2.3		Calcein AM	Mouse mdr1a expressing LLC-PK1 cells	Schwab, 2003
ABCB1	MDR1, P-gp	Nelfinavir	1.4		Daunorubicin	Caco-2 cells	Choo, 2000
SLCO1B1	OATP1B1, OATP-C, OATP2, LST-1	Nelfinavir	0.93		Estradiol-17beta-glucuronide	HeLa-OATP1B1	Tirona, 2003
ABCC4	MRP4	Nelfinavir	97		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC2	MRP2, cMOAT	Nelfinavir	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Nelfinavir	>133		Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLCO2B1	OATP2B1, OATP-B	Nelfinavir	0.9		Estrone sulfate	MDCK II-OATP2B1	Kis, 2010
SLC22A5	OCTN2	Nelfinavir		29.2	L-carnitine	MDCKII-hOCTN2	Diao, 2009
ABCG2	BCRP, MXR	Nelfinavir	13.5		Pheophorbide A	MDCK II-BCRP	Weiss, 2007
ABCB11	BSEP	Nelfinavir	11.8		Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A1	OCT1	Nelfinavir	21.8		Tetraethylammonium	HeLa-OCT1	Zhang, 2000

No drug-drug interaction information.