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Nateglinide

Substrate Information
Inhibitor Information
Clinical Drug-drug Interactions

In Vitro Substrates

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Km (μM) Cell System Reference
SLCO1B1 OATP1B1, OATP-C, OATP2, LST-1 36.4 HEK-OATP1B1 Izumi, 2015

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In Vitro Inhibitors

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter
Transporter Synonyms Inhibitor IC50 (μM) Ki (μM) Substrate used Cell System Reference
SLC22A8 OAT3 Nateglinide 0.86 6-CF COS-7-OAT3 Duan, 2012
SLCO1B3 OATP1B3, OATP8 Nateglinide 45.6 CCK-8 MDCKII-OATP1B3 Meyer, 2014
ABCC3 MRP3 Nateglinide 104 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC2 MRP2, cMOAT Nateglinide >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCC4 MRP4 Nateglinide >133 Estradiol-17beta-glucuronide Sf9 cell membrane vesicles Morgan, 2013
ABCB11 BSEP Nateglinide >133 Taurocholate Sf9 cell membrane vesicles Morgan, 2013

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Clinical Drug-Drug Interactions

No drug-drug interaction information.


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