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Naproxen

In Vitro Substrates

No substrate information.

* denotes drugs that can potentially be used for in vivo (clinical) studies of the designated transporter

Transporter	Synonyms	Inhibitor	IC50 (μM)	Substrate used	Cell System	Reference
SLC22A8	OAT3	Naproxen	4.75	6-carboxyfluorescein	HEK293-OAT3	Zou, 2021
SLC22A6	OAT1	Naproxen	3.23	6-carboxyfluorescein	HEK293-OAT1	Zou, 2021
SLC22A6	OAT1	Naproxen	5.8	Adefovir	CHO-OAT1	Mulato, 2000
ABCC2	MRP2, cMOAT	Naproxen	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC3	MRP3	Naproxen	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
ABCC4	MRP4	Naproxen	>133	Estradiol-17beta-glucuronide	Sf9 cell membrane vesicles	Morgan, 2013
SLC22A11	OAT4	Naproxen	85.4	Estrone sulfate	S2-OAT4	Khamdang, 2002
SLC22A8	OAT3	Naproxen	4.67	Estrone sulfate	S2-OAT3	Khamdang, 2002
SLC22A6	OAT1	Naproxen	5.67	Para-aminohippurate	S2-OAT1	Khamdang, 2002
SLC22A6	OAT1	Naproxen	4.13	Para-Aminosalicylic acid (PAS)	HEK293-OAT1	Parvez, 2017
SLC22A8	OAT3	Naproxen	4.6	Para-Aminosalicylic acid (PAS)	HEK293-OAT3	Parvez, 2017
SLC22A7	OAT2	Naproxen	486	Prostaglandin F2-alpha	S2-OAT2	Khamdang, 2002
ABCB11	BSEP	Naproxen	>133	Taurocholate	Sf9 cell membrane vesicles	Morgan, 2013

No drug-drug interaction information.